In contrast, CD4+CD25+ Treg are implicated in the protective mechanism of DNA vaccination against experimental autoimmune uveitis [18] which suggests that the role of Treg during DNA vaccination differs between the different disease models and/or immunization regimens.
One explanation for the differing results observed in these different disease models is that SHRs are also known to have dyslipidemia and impaired glucose tolerance, making their failure to respond to iPOST difficult to attribute entirely to hypertension (van den Brandt et al., 2000).
Some of these differences may be due to the different disease models studied.
However, the observation of similar phenomena in different disease models, using different animal strains, makes this explanation somewhat unsatisfactory.
Rather, the lab was using lots of different disease models to study IBs- from Cystic Fibrosis, to HD, and more.
Abundant preclinical research on different disease models has shown that UCMSCs can accelerate wound or nerve damage recovery and suppress tumor progression.
The apparent migration and homing abilities of MSCs without tumorigenic potential were described by several groups and in different disease models [51 54].
Notch signaling is critically involved in macrophage differentiation and activation in different disease models (Wang et al., 2010; Zhang et al., 2010; Xu et al., 2012; Franklin et al., 2014; Zhao et al., 2016).
IL-25 has been shown to be able to directly act on M2 macrophages and induce production of type 2 cytokines in different disease models (Cao et al., 2011; Rizzo et al., 2012).
We generated two different disease models.
Furthermore, studies with transgenic animals recapitulated very similar early pathologic events for different disease models [9] [12].
