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Relative comparisons of genomic copy-number profiles by unsupervised hierarchical clustering enabled us to categorize gastric intramucosal neoplasms according to lineage-specific patterns of CNAs and different degrees of genomic copy-number instability as stable, unstable, and intermediate.
Breast tumor subtype classification remains a complicated issue due to difficulties associated with the presence of multiple interacting factors such as the presence or absence of node-filtration, ER-positivity, metastatic potential, different degrees of genomic instability, and tumor cell origin.
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Patterns of CpG and UpA under-representation among viruses infecting hosts with different degrees of host genomic DNA methylation have remained similarly unexplored.
The G + C content of these genomes correlates with adaptation to different degrees of light intensity, and the rapid genomic divergence may be tied to the rapid ecological divergence of these clades.
Variants of this approach have been used to search for the genomic binding sites of 7 nuclear receptors, each technique having different degrees of bias in terms of the genomic regions probed, resolution, amplification of DNA fragments, analysis algorithms, and other factors [2].
Differentially methylated regions (DMRs) are genomic regions showing different degrees of DNA methylation in multiple samples.
Our results demonstrate that rice TEs are localized in genomic environments with different degrees of methylation characteristic of the particular TE.
Recent studies by transposon-methylation display (TMD) showed that in the rice genome various TEs (including mPing) appeared to reside in genomic regions with different degrees of cytosine methylation modifications [ 50].
We can estimate strong selection by comparing the prevalences of low-frequency polymorphisms in different genomic compartments that likely experience different degrees of constraint.
Although the various subspecies of F. tularensis share considerable genomic content (>97% nt identity), they exhibit different degrees of virulence (3 ).
A tumor progression model for human HCC based on bioinformatic analysis of genomic data was able to identify three subgroups of patients with different degrees of tumor progression [3].
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