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Differentially methylated regions (DMRs) are genomic regions showing different degrees of DNA methylation in multiple samples.
Different degrees of DNA methylation cause diverse effects depending on the sub-class of CpG-island present.
This analysis also showed that some GBM samples were more strongly altered than others and we observed three main GBM clusters displaying different degrees of DNA methylation alteration.
For Lung tumor incidence, and for the frequency distribution of the different degrees of DNA damage between the experiment groups in SCGE assay, significance of the difference was determined by chi square test.
A second explanation is that the peaks detected by flow cytometry do not consist of populations of cells with different numbers of chromosomes or different amounts of DNA, but instead, consist of populations of cells with different degrees of DNA compaction.
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RIDGES have a different degree of DNA compaction as suggested by computational analysis [ 83], an assumption, which is backed by the fact that the genomic characteristics of RIDGES largely overlap with those recently defined for DNA domains in an underwound state [ 84].
Patterns of CpG and UpA under-representation among viruses infecting hosts with different degrees of host genomic DNA methylation have remained similarly unexplored.
In a situation where a duplex real-time PCR assay or two separate singleplex assays are used to compare abundances of two different target regions in a sample of fragmented DNA, it is crucial that the quantitative detection of the two targets is not influenced by different degrees of degradation of the target DNA sequences leading to incorrect quantities of the respective target.
He says this is the first demonstration that different degrees of sexual selection influence the DNA sequence of a reproductive gene.
For example, the variation in transgene expression resulting from inserting the T-DNA into different parts of the genome which have different levels of transcriptional activity (the so-called "positional effects") can result in lines in which genes are silenced with different degrees of efficiency, despite being transformed with the same T-DNA construct [11].
We examined the effect of different degrees of adjustment for potential confounders on the association of bulky DNA adduct levels on birth weight.
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