Sentence examples for different classes of sites from inspiring English sources
Although recent studies have been able to leverage population genetic data to identify differences in the amount of purifying selection acting on different classes of sites (Pierron et al. 2012; Ward and Kellis 2012; Somel et al. 2013), we attempt to classify individual genomic regions as constrained or unconstrained by selection.
To compare the selective constraint on different classes of sites, we used two statistical tests.
If the epigenetic patterns at different classes of sites have the same latent structure, the discovered class-specific codes will be very similar or interchangeable.
In contrast, antisense sites that may be associated with transcription from nearby genes or orphan antisense PACs were more similar to sense-oriented sites that fall within protein-coding regions; especially apparent are the pronounced elevated A contents and reduced U contents downstream from these different classes of sites.
Although less accurate for individual sites, the estimates based on TMT quantification were comparable to SILAC for different classes of acetylation sites (Appendix Fig S2C) and are presented in Dataset EV2 as an additional resource.
We computed the sequence affinity of the different classes of binding sites to the canonical CTCF consensus motif in mouse and found that the levels of motif affinity for conserved sites were overall higher than the level for the mouse-divergent sites.
The Freundlich model is suitable for a highly heterogeneous surface composed of different classes of adsorption sites.
(B – B′ ) Band shift experiments between Nv HoxB or Nv HoxE and Nv Pbx on the three different classes of binding sites, as indicated.
These results show the existence of different classes of binding sites, those that are rather generally accessible, and a larger set that are occupied in a cell type-specific manner.
(A ) Nucleotide sequence of the different classes of Hox/Pbx binding sites used in band shift experiments.
Because of CTCF's diverse roles in genome regulation, different "classes" of CTCF binding sites might exist to carry out different functional roles.
