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The main challenges originate from three different classes of effects.
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Each of these modes of action has been well described in the literature for two different classes of chemicals with antiandrogenic effects.
The process of identifying causal relationships between different classes of pollutant and their effects has to be extended using numerous approaches already proven in ruminants.
In the present study, we show that the different classes of drugs exhibited distinct effects on the RA-induced signature in human chondrocytes.
A different class of growth effects is related to dislocations.
However, different classes of flavonoids have different effect on disease risk and the relationship between flavonoid intake and risk of disease appeared to be non-linear.
To further complicate the picture, different classes of CSPGs may exert different effects on OPCs [ 160].
Different classes of PtdIns3Ks exert distinctly different effects: class I Ptdlns3K inhibits autophagy, whereas class III Ptdlns3K stimulates autophagy (Petiot et al., 2000).
Finally, the current review includes a quantitative synthesis of all currently available effectiveness data from experimental vaginal microbicides; but the Cochrane review conducted a narrative synthesis of effects across the different classes of non-nonoxynol-9 microbicides.
Taking different classes of drugs did not have marked effects on blood levels of any THM, although there were borderline significant effects in the anticipated direction for bromoform with respect to taking CYP2E1 inducers (p = 0.08) and substrates (p = 0.05), the effect of which would be to increase metabolism and lower parent compounds in the blood.
A population bottleneck is also expected to similarly effect different classes of repeats (Gherman et al. 2007), which is consistent with our discovery that all three superfamilies we investigated show amplifications in A. thiersii.
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