The Akaike information criterion (AIC) [ 27] and Bayesian information criterion (BIC) [ 28] belong to a different class of model selection measures that compare all of the models simultaneously according to some measure of fitness.
Of course, one could move to different classes of models where monotonicity does not hold, for instance neighborhood models.
A researcher has the option of using different classes of models for the modeling of the observed as well as the unobserved price changes of a time series.
However, different classes of models with different numbers of parameters whose values are unknown have to be considered.
Over the years, observations supporting one or more of these different classes of models have been made.
Signaling networks provide a means to link these different classes of models, connecting drug exposure, through molecular activities, to clinically relevant responses.
(Note that, whilst comparisons within Tables are valid, comparisons between DICs presented in Table 3 and Table 4 cannot be drawn, as they represent different classes of models, one with and one without a latent correlation structure).
Two different classes of models were implemented in the codeml program: "branch-specific" (which permit a different ω ratio in U. gibba; Yang 1998) and "branch-site" models (which also accounting for uneven selective pressures along sequences; Yang and Nielsen 2002).
We have hence measured the computation time for the different classes of model present in this paper and have listed the results in Table 5.
There are many different classes of model that can explain the relationship between gene expression and disease, leading to different types of TRS, including weighting of the eQTL effect size, only considering extreme expression values, and incorporating the structure of the affected pathway into the analysis.
