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Importantly, differences in different cellular contexts are particularly notable when comparing stem cells and established ESFT cell lines.
Investigating this context-dependent binding of TFs and the causes of binding differences across different cellular contexts is therefore fundamental for understanding gene regulation in general, and also for understanding how differential binding by TFs contribute to disease development.
This difference is probably due to the diverse effects of PAF in different cellular contexts.
In our view, these two models are not in conflict with each other and may function alternatively or collaboratively in different cellular contexts.
Here, we examine the input-output properties of the Raf-MEK-ERK MAP kinase module in mammalian cells activated in different cellular contexts.
It is unclear how podocalyxin mediates these distinct effects in different cellular contexts.
Many other important survival proteins are regulated by either caspases or the proteasome (but not both) in different cellular contexts.
These results indicate that many aspects about the mechanism of TIEG proteins still remain unknown and suggest that TIEG might be using alternative mechanisms in different cellular contexts.
Therefore, any molecular models have to be pieced together on the premise that mechanisms are the same in different cellular contexts.
This functional redundancy suggests selective targets for the different family members, allowing the family broad potential to protect against varied stresses in different cellular contexts.
It must be noted that PI3K is involved in FGF-2-dependent but not in VEGF-dependent PLCγ1 activation suggesting that different mechanisms of PLCγ1 activation exist in different cellular contexts.
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