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The two key concepts of third generation systems are 'consolidation' (i.e., combining different analytical technologies or strategies on one instrument or on one group of connected instruments) and 'integration' (linking analytical instruments or group of instruments with pre- and post-analytical devices).
It aims at quantitative analysis of all low molecular mass metabolites and searches for the relationship between metabolites and changes in physiology and pathophysiology by combining different analytical technologies with calculation methods.
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For validating models of metabolism metabolomics will play a key role; however, metabolome coverage needs to be enhanced by combining different analytical procedures and novel technologies.
The discrepancy is possibly due to the different sensitivity of the two analytical technologies, SRM-MS being more sensitive than MS/MS.
Early signs of success have been evident in fields of cardiovascular risk and cancer using MS technology with a different analytical paradigm: small molecules instead of shotgun proteomics.
RTR specification with mathematical model and different approaches to multivariate statistical process control supporting process analytical technologies are also presented.
According to their detection technology and detection means, the selection of different analytical methods of pesticide residues for the control of the quality and safety of TCM should meet the social demand for rapid identification of medicinal species.
The lack of concordant gene signatures could be related to several issues, including differences: (1) in technological platforms, such as microarray, RT-PCR or sequencing technologies; (2) different sample types selected for analysis, and (3) the different analytical tools used to generate the gene signatures [ 22].
Three-dimensional fluorescence spectroscopy, a kind of new fluorescence analytical technologies developed in the past 20 years, can visually show the microenvironment and conformational changes under different conditions of Trp in protein molecules.
However, these participant-level inferences required a different analytical approach from traditional model-based fMRI.
CI was calculated utilizing different analytical approaches.
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