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Differences within the apo vs. ligated LAOBP hydrogen bond networks are plotted in Fig. 6.
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Notably, there are no significant structural differences between the apo transport domains in the outward- and inward-facing states.
Using the Student's t-test, we found that there was no statistically significant difference (P<0.005) between the twelve R403Q reconstructions within each condition (Figure 2C,D), but a statistically significant difference between the apo and the ADP state (Figure 2B).
Surprisingly, in the two examples of ligated and apo structural pairs, the number of H-bonds within the ligated complex is smaller than the number within the apo structure.
Consistent with our results, the same C p max reduction within the apo form of HBP is observed within the experimental DSC curves [27].
This enzyme is part of a complex that edits a translational stop codon within the apo B mRNA, causing synthesis of apo B-48 (present on chylomicrons) instead of the full-length apo B-100.
Differences in the apo- and biotin-bound conformations of SA were clearly shown by calculating alignments of the loops connecting the β-strands (Table 2).
These data indicate that a single haplotype, X+Del, within the apo B gene impacts lipid metabolism and may contribute to CHD susceptibility in Brazilian males.
"There are differences within the regions.
But there are differences within the coalition.
Consistent with the hinge motion inferred from Fig. 3b c, differences within the H-bond network between the apo/ligated pair primarily occur within non-secondary structure elements (refer back to Fig. 6).
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