Recently, Dafny and colleagues reported strain differences in sensitization to the locomotor activating effects of methylphenidate between Sprague Dawley (SD), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, the extent of which was shown to depend on age [ 9- 11], reviewed in [ 12].
In a separate experiment, transcriptomic data was collected via total RNA isolation followed by hybridization to whole-genome gene expression arrays to compare gene expression differences in the hippocampus between allergen-sensitization or saline-treatment in W sh /+ and W sh /W sh littermates as well as unrelated wild-type (WT) mice.
Further research is also needed to determine gender differences in the neural substrate underlying incentive sensitization processes and how it may be involved in psychopathologies characterized by gender-specific courses, such as schizophrenia, substance use disorders and major depression.
Although both siRNAs appeared equally efficient at the protein level, siBRCA1_14 was markedly less efficient than siBRCA1_13 at the mRNA level (residual amount of BRCA1 mRNA was 24% for siBRCA1_14 versus 16% for siBRCA1_13; Figure 1d), which likely explains the differences in sensitization to bortezomib.
Moreover, there were no differences in food allergen sensitization or house dust mite sensitization between these 2 groups (data not shown).
Overall, there were no large differences in the association for asthma with and without sensitization (P-values for interaction between maternal BMI and sensitization were all non-significant).
The observations that HLA-DR3.IFN-γ−/− transgenic mice are resistant to lethal TSS without D-galN sensitization which mimics human TSS, but are still susceptible TSS with D-galN sensitization underscored significant differences in the immunopathogenesis between the two models of TSS.
Sensitization is due to differences in the work function between regions of covered platinum and uncovered ZnO nanoparticles.
72 In a mouse model, difference in the timing of LPS exposure led to totally opposite responses: protecting against sensitization if exposed early in the sensitization process; exacerbating inflammation if exposed after the sensitization process.
Similarly, we found no differences in sensitization to cat, dog, Ascaris or α-gal (data not shown).
