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The two ionization chambers showed 10%to12%2% differences in the radioactivity measurements even though both detectors had been identically calibrated.
Furthermore, differences in the radioactivity concentrations expressed in %ID/cc or SUVs in the tumour were observed between the different rat strains regardless of body weight.
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This explains why we did not observe any difference in the radioactivity concentration in the blood between different antibody administration lag times with pretargeted trastuzumab.
There were also no significant differences in the accumulated radioactivity in tumors observed among animals that received either labeled or unlabeled non-transgenic AC133+ cells.
There was no difference in the blood radioactivity before and 5 h after isotope administration, as it was the same as the background radioactivity.
Briefly, there were neither statistically significant differences in the decrease of serum radioactivity nor in the (very fast) urinary excretion of radioactivity for the three compounds.
The average estimated difference between the radioactivity in the standard in the image and the amount dispensed as measured by the dose calibrator was +2.0 ± 8.5 % with a range of −16.2 to +24.2%%.
In addition we determined the difference between the radioactivity in the nucleated cell fraction of the bone marrow, including the stem cells, and that in the blood to determine whether there was any difference that could be attributed to the specific binding of the radiopeptide to somatostatin receptor-positive cells in the bone marrow.
To control for differences in the absolute counts of radioactivity between replicates, data were first normalized to DMSO (set to 100%) within each replicate, then averaged across three biological replicates.
There were no significant differences in injected radioactivity or specific radioactivity between the AD patients and the control subjects for either [C]AZD2995 or [C]AZD2184 (p > 0.05).
It was considered that the relatively large differences in radioactivity concentrations of the EXP polar map, as shown in Figure 5, compared to the MID or the INS polar maps were due to the results over all subjects, but was not from outliers.
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