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There were inter-study volume differences between the pilot and the replication studies and intra-study volume differences in the pilot alone.
We did not adjust the existing differences in the pilot intervention, however; this was out of the scope of the current pilot feasibility study which aimed to assess effectiveness, practicality and acceptance in the local settings.
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The difference in means in the pilot study (5.1 0.91=4.19) was not used as the basis for the power calculation as the difference in the pilot study was likely to be larger than the difference observed in the current study where both groups received morphine.
The differences between the AMA-1 and MSP-119 estimates in detecting changes in transmission may be linked to differences in seroconversion and reversion rates and this could also explain the differences observed in the pilot study.
The differences observed in the pilot year were similar but of lesser magnitude during the first two semesters the course was fully offered.
Wang and Lu (2015) focused on the differences in the 6 pilot regions and found that the macroperspective has a positive effect on carbon price.
"And the main difference is in the pilot's vision which, unlike in the traditional use where they never lose sight of the drone, the pilot doesn't see his drone, but only what the camera of his drone is revealing".
Except where we draw attention to differences, all items in the pilot questionnaire were identical to those in the final questionnaire [see Additional file 2].
The only differences with methods used in the pilot phase were: 1) the time needed to fill out the NDI and COM was not registered, 2) only one version of the questionnaires was given (NID and CSC6 were not used), and 3) patients were not asked about their comprehension of each item in the questionnaires.
All differences between the pilot patients and GPPS highlighted in the Results are statistically significant at the 95% level.
Standard differences between the Pilot participants and controls were calculated for the variables included in the propensity score.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com