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The different parts of the genome have differences in the mutation rate and the accepted selection pressure.
Differences in the mutation rate in different parts of the genome would contribute to this rate variation, as would differences in the number of sites under nonthermodynamic constraints such as the requirements of functionality (Zuckerkandl 1976).
In MMR-deficient cells, significant differences in the mutation rate were observed among these DNA sequences reflecting the different rate of replication errors.
Furthermore, there were differences in the mutation rate among autosomes.
For calculating statistical differences in the mutation spectrum data the chi-squared test was used.
This is not caused by differences in the mutation rate (Burton et al, 2002).
Similar(23)
Previous studies have found little difference in the mutation rates or mutational spectra of mutL and mutS mutant strains (Schaaper and Dunn 1987).
Since the possibility of mutations can be considerably greater in the latter setting, this can give rise to qualitative differences in the mutation-selection dynamics.
This is likely due to differences in the mutations between the two families and their effects on PIG-Y protein function.
The total number of mutations per strain ranged from 23 to 240; however, there was no significant difference in the mutation load arising from different 4-NQO doses and kill percentages.
No difference in the mutation frequency was observed between the Greek and Romanian population.
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