The study highlights the complex relationships between DNA breaks, cytogenetic aberrations, protein-DNA complexes and drug cytotoxicity, and shows that the relationships differ for adriamycin and amsacrine, suggesting some differences in the modes of action and/or resistance for the drugs and cell lines.
The reason for this disconnect lies, in greatest part, in the differences in the modes of storage and transmission of the particular kinds of information in the organic vs. the material cultural realm.
Herein, we demonstrate that the differential activation of T cell immunity reflects differences in the modes of intracellular trafficking and distinct biodistribution of the Ag in lymphoid organs, which are both driven by the properties of each nanocarrier.
The present study considered placental development as a potential target of BPA and investigated potential differences in the modes of action of two doses of BPA by a toxicogenomic approach.
However, the subtle structural differences that have recently been observed across a variety of families shed light on their functional diversity, including variations in mechanism of action, differences in the modes of substrate binding, and substrate-assisted orientation of catalytic residues.
Altogether, these observations reveal remarkable differences in the modes of axon growth of PCs dissociated at distinct developmental times, suggesting that their competence for neurite elongation varies with age.
This anecdotal evidence implies differences in the mode of transmission between different genetic variants of mtDNA.
Since it was not the principal aim of this study to elaborate further the differences in the mode of cell death induced by different mycotoxins, no further experiments were conducted.
Despite differences in the mode of evolution inferred, this result was consistent using three different methods to infer the history of amino acid transporter gene families in our phylogeny thus, revealing a strong underlying signal.
However, the differences in the mode means were larger for vocabulary (0.23) and fluency (0.19) than for grammar (0.05).
