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The functional consequences of Spc105 inactivation differ among species presumably reflecting differences in the hierarchy of kinetochore assembly and in the roles played by kinetochores in chromosome segregation: de novo MT capture, for example, is more important in human cells than in budding yeast, in which kinetochores remain MT-bound throughout the cell cycle.
The results indicate differences in the hierarchy of influential input factors between the screening and quantitative methods.
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This revealed reproducible differences in the hierarchies of peptide dissociation between tapasin-jun and TAPBPR on HLA-A2.
As viral protein expression is influenced by the cell types and organs that are infected [19] [21], we might expect some differences in the immunodominance hierarchy elicited by ΔgL and replication-competent K181 MCMV.
Specifically, they suggest that differences in the cellular hierarchy exist between tissues predominantly consisting of mature or immature lobules.
Further, we elucidated the structural and anatomical location of undifferentiated progenitor cells within the breast lobules and identified specific differences in the cellular hierarchy that exist between tissues predominantly consisting of mature or immature lobules.
As our data suggest underlying differences in the epithelial hierarchy between breasts with immature and mature lobules, studies examining the correlation between the lobule types present in the normal tissue matched with the specific breast tumor subtype could potentially clarify the differences between rodent and human models of breast cancer.
A hierarchical cluster analysis was performed to identify differences and similarities in the hierarchy structure of the different practices.
These results reveal underlying differences in the human breast epithelial hierarchy and suggest that with increasing glandular maturity, the epithelial hierarchy also becomes more complex.
We conducted a secondary analysis of FSS data from three different studies of samples with potential diagnostic differences in item hierarchy.
A differently ordered hierarchy might indicate differences in the availability and usefulness of the specific sugars in the evolutionary environment of different species.
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