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MGR (Bourque and Pevzner 2002) was used to calculate the minimum number of rearrangements needed to explain the differences in the genomic architecture between the selected genomes.
To address the point of how stable this pattern was under different transcriptional regimes, we searched for differences in the genomic distribution of nucleosomes in exponential vegetative cells and at different stages through meiosis.
This study thereby represents the first in depth collective analysis of MSRs in different populations to identify commonalities and differences in the genomic regulation of MSRs.
Based on differences in the genomic composition of bacterial and eukaryotic genomes, supervised and unsupervised classification methods have been developed, such as the Naïve Bayesian classifier [ 24] and the neural network Self-Organizing Maps (SOM) [ 25].
Among these mutation sites, 15 sites were different from the database sequence, but not real differences in the genomic loci as revealed by Tajima et al. (Table 2).
Despite consistently high levels of variation, there are major differences in the genomic organization of MHC genes in different vertebrate groups.
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Thus, the APC/MCC pair provided an excellent example to showcase our cross-species comparison strategy, utilizing the difference in the genomic location of orthologous genes in different species to distinguish between cancer driver and passenger alterations.
Similar to the original assumption by de Vries et al.[16], we hypothesized that these phenotypical differences may reflect a difference in the genomic defects underlying the disorder.
To further confirm the absence of any difference in the genomic region corresponding to Variation_7105 between patients and control individuals, direct competitive hybridization of patient II.5 in pedigree D versus control n°11, both belonging to Cluster 1 (Figure 3B, Figure S2), was performed (Figure S4, panel C); as expected, this experiment did not reveal any significant difference.
Despite the difference in the genomic distance in these two datasets, the best value of α is consistently around 0.50.
There was no difference in the genomic structure of GsAG2 between the double-flowered mutant and the wild-type cultivar (data not shown).
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