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In the same study, the type and position of TP53 mutations also differed between the two tumor types, again suggesting molecular differences in the genetic mechanisms of bladder carcinogenesis depending on underlying etiology.
For example, there are potentially important differences in the genetic mechanisms that cause phenotypic variation among intraspecific and interspecific taxa (especially in morphology [ 18, 19]; see also [ 24]).
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Similar patterns were observed at some microsatellite loci in an earlier analysis of a dataset from a larger number of populations in the same area (see e.g. Figure 2b of [ 29]), and they may point to differences in local selection regimes that are not consistently related to altitude, or to differences in the genetic mechanism of adaptation to the same local selection regimes.
Furthermore, this study of skeletal muscle transcriptional profiles is helpful in understanding the differences between the genetic mechanisms in TC and YK pigs, and for future work exploring breed-specific changes in muscle development.
Comparison of transcriptome of skeletal muscles and other tissues between phenotypically different pig breeds has been proposed to improve the understanding of the genetic mechanisms underlying differences in growth and meat quality [ 10].
To understand the genetic mechanisms underlying differences in virulence of fungal isolates on various arthropod pests, we compared the chitinase genes, chi2 and chi4, of 8 isolates of Metarhizium anisopliae.
This information, particularly in conjunction with QTL mapping or genome-wide association results, should be useful for future work aimed at better understanding the genetic mechanisms underlying phenotypic differences in cattle.
Futher functional and genetical studies may be focused on the LW breed with its increased mortality at birth, and then be continued to identify the genetic mechanisms underlying the differences in maturity.
Here we initiate investigations of the genetic mechanisms that underlie population differences in thermal tolerance observed in Tigriopus californicus[ 32].
These three gene sets are anticipated to be key to elucidating the genetic mechanisms that underpin phenotypic differences in the physical fiber traits of the two species.
Further efforts should be made to intersect our eQTL data with IBD and CRC genetic studies, for a better understanding of the genetic mechanisms and inter-ethnic differences in these diseases.
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