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Taken together, our results show that the overall strength of oligomerisation was conserved during the evolution of members of the p53 family, while subtle differences in the equilibria may play a role in fine-tuning their biological activity.
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The observed differences in dissociation equilibria of the human paralogs may have important biological implications for interactions with regulatory proteins, such as members of the S100 family, which have been shown to differentially bind different oligomeric states of p53 [ 38, 39].
The value most often calculated is p Ka oct, using log P and log PI obtained from two-phase titrations, and the aqueous p Ka. Since the diff terms of eq 2c represent differences in equilibria corresponding to differences in free energy, they are also free energy terms.
The Gibbs Thomson relationship for a ternary system, as well as differences in measured phase equilibria with CALPHAD assessments, are considered in great detail.
Differences in the rock types in the reaction zone can lead to large variations in the hydrothermal fluid chemistry, because the bulk chemical composition and primary minerals in the source rock control the reaction sequences and their chemical equilibria.
In particular, the equilibria we analyze are "conditionally" dominant strategy in a precise sense.
According to Theorem 3.1, this difference will lead to the equilibria without predator, and the equilibria without predator is unstable.
In this paper, we investigate fitness landscapes (under point mutation and recombination) from the standpoint of whether the induced evolutionary dynamics have a "fast slow" time scale associated with the differences in relaxation time between local quasi-equilibria and the global equilibrium.
So we've got both the equilibria in the sub-game.
In this section we focus on those sample paths that converge to an equilibrium, and examine the differences between distinct equilibria.
The equilibria in this case are shown below.
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CEO of Professional Science Editing for Scientists @ prosciediting.com