This may be explained by the differences in the end points of both assays.
In semantic terms, we have chemicals that produce differences in the end points claimed for hormesis but that may not translate to variable strength in hormetic responses.
These results are consistent with some earlier studies but not others; the authors suggest the apparent contradictions may result from differences in the end points studied and the timing of exposure assessment.
However, aside from age (median age, in good control=59, not in good control=55; p=0.010), no other significant differences in the end points measured postimplementation were noted among those with 'good glycemic control' against those 'not in good glycemic control'.
The effect of CO exposure was determined from the percent difference in the end points obtained on exercise tests performed before and after a 1-hr exposure to room air or CO.
Because all glycemic indices reached their lowest level between 15 and 27 months (arbitrarily defined nadir point), we defined ΔGA/HbA1c as the difference in GA/HbA1c between the end point (39 to 51 months) and nadir point (15 to 27 months).
There are currently also major differences between the end points used in preclinical animal studies and clinical trials.
From the observed subject-specific differences in the end-point responses, the percent difference between the two treatment groups, relative to the overall subject-specific mean values of the RM-131 and placebo values, was also calculated (see above).
Inclusion criteria included RCT with minimum 6 months duration, with participants having BMI≥25·0 kg/m, a diagnosis of T2DM using HbA1c, and no statistically significant difference in mean weight loss at the end point of intervention between dietary arms.
For patients with discordant visual acuities at baseline, there was a 45% difference in the responders for the best recovery of visual acuity (P = 0.024); and a 32.5% difference in the end-point assessing the change in visual acuity for all eyes (P = 0.011).
The main outcome of interest for this review was the mean difference in HbA1c between dietary arms at the end point of intervention.
