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Considering the similar dosing periods, the greater response at the ALI compared to suspension is likely due to different particle physical/chemical characteristics rather than to differences in the dosing period.
These conflicting results may be due to differences in the dosing regimens used in each study.
There were also differences in the dosing of medications between the two trials; in the CLASS trial a higher dose of celecoxib 400 mg b.d. was used compared with celecoxib 200 mg b.d. in the CONDOR trial.
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This example stresses the need to take into account age-related differences in the dose-concentration relationship between children of different ages and adults when interpreting efficacy studies.
Debate continues over differences in the dose-response functions used to predict the annoyance at different sources of transportation noise.
Similar results were obtained with MCA38 and 4T1 cells, with some differences in the dose threshold at which Trex1 upregulation was sufficient to markedly decrease cytosolic dsDNA, which was 15 Gy in both MCA38 and 4T1 cells (Fig. 7b,c).
The inconsistent results of previous studies have been attributed to differences in the doses, timing, and routes of administration of EPO.
However, post hoc analyses of patients enrolled in two participating centers of the original low tidal volume trial did not detect differences in the dose or duration of sedatives and opioids between low tidal volume and control groups [2],[3].
This may suggest possible differences in the dose-response relations to overweight and obesity.
Species differences in RA sensitivity and/or differences in the dose of RA (150 µg vs 1 mg/kg/day) may explain the discrepancy between these studies.
Therefore, differences in the dose regimen would have almost no impact.
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