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Lee et al. [ 12] used MRI scans with bulk density information assigned for soft tissue and bone, and showed that there were negligible differences in the dosimetry when compared with CT-based planning.
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Table 2 summarized the differences in dosimetry of the bladder and rectum for IMRT and IG-IMRT groups.
We hypothesized that assessment of myocardial sympathetic activity with no-carrier-added (nca) I-meta-iodobenzylguanidine (MIBG) compared to carrier-added (ca) I-MIBG would lead to an improvement of clinical performance without major differences in radiation dosimetry.
Zoetelief and Jansen [25] compared protocols for dosimetry in mammography and concluded that the use of different radiation transport codes and different spectra could cause differences in the conversion factor g by up to about 7%%.
This recursively confirms that the differences in the results of the two small animal-based dosimetry approaches (organ harvesting or imaging method) are really due to methodological differences as described above.
Our work adds to the body of knowledge on 90Y dosimetry in part by assessing absorbed dose differences in the patient data due to differences in methodology.
Additionally, due to their smaller body sizes and potential differences in radiotracer uptakes, dosimetry calculations performed for adult subjects may not be appropriate for children.
In addition, we hypothesized that this improved myocardial uptake of nca I-MIBG would not lead to any major differences in dosimetry.
As discussed in the "Dosimetry" section, the risk of fetal damage is negligible during routine SNB procedures.
Dosimetry calculations indicated that this critical parameter could vary considerably due to differences in the rate of clearance of radioactivity from the resection cavity and the resection cavity volume.
Because extrapolation of experimental studies in laboratory animals to the adverse health effect in humans is a central interest, we will be particularly interested in comparing the structure of the gas-exchange region of different species and the implications that these differences in structure have on dosimetry.
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