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Heterogeneity among AML patients reflects differences in the constitutive expression of signaling proteins in leukemic cells.
Our AHR binding analysis provided strong indications of AHR binding for AHR-related differences in the constitutive regulation of genes.
The expression of CYP19 was determined at the transcript and protein levels, and no significant differences in the constitutive expression were found between the cell lines tested.
Unlike IL-33, there were no differences in the constitutive expression of IL-1β among MS, HC, and OND groups (Fig. 3A).
These results indicate that, although there are differences in the constitutive levels of HSPs between testis and bladder cancer cells, both cell types are capable of mounting an induced heat shock response and can develop a similar degree of thermotolerance.
Differences in the constitutive and induced expression levels in T- and S-oaks were observed for a number of transcription factors, including, e.g. several members of the ERF (ethylene-responsive factors) and WRKY transcription factor families.
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We next wondered if this difference in the constitutive IL10 mRNA level between adults and neonates could explain the difference in chemokine responses after CpG administration.
It stands to reason that if there is a significant difference of an analyte X between case and control populations, there should also be a significant difference in the constitutive subpopulations.
There was no difference in either the constitutive or induced level of IL-33 in patients on immunomodulatory therapy when compared to those on no therapy (Fig. S1).
In particular, a difference in the relevant constitutive property is sufficient to distinguish events such as Caesar's death, construed as Caesar's exemplification of the property of dying, and Caesar's violent death, construed as his exemplification of the property of dying violently [Kim 1976].
The apparent "characteristic length" of Htt-ex1 fibers is in contrast to other amyloidogenic proteins that grow much longer in a predominantly linear fashion with some branching, suggesting differences in the conformations of the constitutive monomers, the packing density of monomers in the fiber strands, or the interactions between monomers along the fiber axis versus perpendicular to it.
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