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The fact that the CRF1 binds Gs and β-arrestin proteins differently in males versus females suggests sex differences in the conformation of this receptor.
Comparison between the two CohB1 structures revealed significant differences in the conformation of their equivalent C-terminal linker segment.
This is likely due to differences in the conformation of the protein at the hydrocarbon water interface as compared to the triacylglycerol water ones.
The spectral investigations also highlight the differences in the conformation, which govern the extent and nature of coiling of the PNA chains resulting in different morphologies.
Are the results due to differences in the conformation in which the purified fragments or recombinant proteins adsorb to surfaces?
This might be caused by the differences in the conformation of Ep63K epitope when it is presented as a soluble peptide or processed from NP-Ep63K protein.
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The latter is attributed to differences in the conformations of surfactants within monolayers and micellar assemblies.
Hence, the slight differences in the conformations of these loops are likely to arise from the crystal contacts, and it seems highly unlikely that they underlie the dramatic functional differences observed between synaptotagmins-1 and -7.
In addition, differences in the conformations of the three aa-tRNAs are found primarily in the T- and D-loops.
Moreover, co-activator interactions were ligand-dependent via differences in the conformations of the PXR-ligand complexes [ 20].
The results of this study show that the size and shape of the aromatic ring system can give rise not only to pronounced differences in the conformations of the PAH diol epoxide DNA adducts formed but also to different extents of distortion of the surrounding DNA structure.
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