The non significant results of the nested anova concerning the recruitment centres imply that is unlikely that the differences between BPD adolescents with and without ADHD could be explained by differences in the centres.
Watanabe et al. [5] have stated that a DO with internal fixation cannot correct angulation precisely due to a difference in the centres of the deformity and that of the osteotomy.
Notwithstanding the somewhat greater reactive-centre diversity of the Arabidopsis serpins compared to that of rice, the substantial differences in the reactive centres of the rice serpins are reminiscent of the oat-grain serpins [ 32] and unlike the glutamine-rich reactive centres in serpins of wheat [ 34] and rye [ 54] grain.
The differences in the reactive-centre sequences of these otherwise closely related serpins might reflect a need to broaden the inhibitory specificity of the rice serpin complement for defence against digestive proteinases from insects or pathogens.
Since the (I/L/V D(S/T G motif, absent in eukaryotic and archaeal PPPs, is involved in organisation of the catalytic centre [ 19], it is possible that this difference in the catalytic centre organisation may be one of the determinants of broad substrate specificity vs. Ser/Thr specificity.
Rabow 2004 found no statistically significant differences in the medical care centre charges incurred during the study period, both aggregated and disaggregated (clinic visits, urgent care visits, ED visits, inpatient services and other charges).
The current ICH E9 guideline recommends that researchers investigate treatment effect using a model that allows for centre differences in the absence of treatment by centre interaction [ 1].
Although the three groups were comparable in sex and age distribution, and the two intervention groups were comparable on the other factors recorded, the groups may or may not have been comparable on unrecorded factors: it is difficult to assess the effects of differences in the DOTS-plus centres involved.
Inspection of within-centre variance (Fig. 1) makes clear the differences in the spatial distribution between Centres 1 and 2 that operated MRI scanners from the same manufacturer and Centre 3. Thus, for a systematic investigation of the consequences, the allocation of participants to the centres was varied.
This difference is less pronounced in the Centre West than other regions (−0.32).
