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However, the plots also indicate the enormous sensitivity of the degree centrality to the threshold level, as significant differences in the centrality values are observed between different thresholds.
But this measure does not account for differences in the centrality of one's friends.
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In general, there was a weak difference in the centrality scores between the genes of selection and nonselection.
However, we did not see any difference in the betweenness centrality of the top ten microRNAs by degree or the top ten genes by degree in the signalling pathways (p<0.089 to p<0.687 for microRNAs and p<0.37 to p<0.987 for genes).
In the nonresponder group, among whom exenatide did not decrease energy intake, there were no differences in eigenvector centrality in the hypothalamic region between exenatide and placebo condition.
(2) There are significant differences in the degree and betweenness centrality between common and specific targets, specifically we observed a significant positive correlation between virus types targeting these nodes and the proportion of hubs, and (3) K-core and ER analysis determined that common targets are closer to the global PIN center.
The area under the curve (AUC) for each ROC was computed for each centrality metric and compared in all subjects using multiple pairwise t-tests with Bonferoni correction to test for differences between the centrality metrics.
In the nonresponder group, we did not obtain significant differences in eigenvector centrality (Fig. 4 C – E ).
We did not obtain significant differences in eigenvector centrality in our region of interest in either of the two groups for rating of nonfood pictures or looking at the fixation cross.
Comparing the average node of proteins within a PPI network built from proteins chosen at random to a network of proteins regulated by miRNAs reveals significant differences in the average node degree, closeness centrality and network stress (p-value <0.0001) (Table 1).
We used Fisher's Exact Test (Fisher 1970) to measure the significance level of the differences in performances between the centrality methods and the baseline method.
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