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Worldwide, C. albicans remains the most common Candida spp. responsible for candidemia, whereas non- albicans spp. compose 40%; however, geographic and age-related differences in the causative Candida spp. have been noted [ 13- 16].
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The difference in the causative organisms may also partly explain the better outcomes than previously reported from north and south India where fungal endophthalmitis was a more common cause of endophthalmitis [13, 20].
Studies of Caucasian and East Asian populations showed ethnic differences in the distribution of causative genes for MED.
This striking difference is difficult to explain but may be partly related to differences in the properties of the causative compounds.
Differences have been observed in the causative pathogens patterns associated with HAP in the People's Republic of China compared to Western countries, with more than half of Chinese patients with HAP caused by Gram-negative pathogens.
There were no significant differences among the causative pathogens.
The fact that these two SNPs were not replicated during the initial assessment of the association signals in the CORGI cohort, together with the North-South discrepancies seen in the PCA analysis, could be a sign of differences in the tagging of the real causative variant amongst populations.
Bacteria that produced ESBL were 16/76 (21.1%) vs. 2/59 (3.4%) (P=.003), and carbapenem-resistant were 10/83 (12.0%) vs. 2/62 (3.2%) (P=.056) in HCAB και CAB patients respectively There are significant differences in the severity of underlying diseases, causative pathogens, antibiotic resistance, outcome and treatment between the two groups.
Due to the differences in causative genes, each renal tumor subtype presents unique morphological, biological, and clinical features.
Although parallels can be drawn from human diseases, the differences in causative agents and interspecies differences has often resulted in failure to identify similar disease mechanisms 127 in veterinary clinical science.
Investigating the role of differences in genetic background, causative mutations, age or sex in this variability requires a very large number of patients for each disorder and, therefore, was not an aim of our study.
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