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The differences in the base statistics in the forward and reverse gene encodings are sufficiently negligible (or disjoint) that their counts can simply be merged in the modeling (data not shown).
For categorical variables, ANOVA was used to identify differences in the base 2 logarithm-transformed ACR.
However, small differences in the base sequence, affecting as little as one nucleotide, can result in a different protein.
There were also significant differences in the base diameter of the lamellar defects for the three groups (F2,89 = 15.184, p<0.0001; table 1).
On the other hand, other miRNAs (i.e., miR-221 and 222; miR-30b and 30a/30e) showed several differences in the base sequence.
Despite differences in the base levels of red-fluorescence, the red-fluorescent signals of all clones increased after treatment with decitabine and zebularine with clone LT1 showed the highest sensitivity.
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No spectral evidence was found for differences in the nucleotide base structure, which is assigned to approximately 1,750 1,300 cm−1.
Therefore, the observed differences in the base-level fluorescence between the diastereomers also reflect different degrees of aligned structures within those apparently amorphous structures.
They assessed the differences in the bases, the letters that make up DNA, keeping tabs on where those differences appeared in the genome and how many existed among the three species.
Techniques that report static structures, such as purely QM optimization or X-ray crystallography may therefore miss key differences in the base-pair helical parameters between non-modified and modified structures.
The thermodynamic differences in the base-pairing stability of the respective 5′ ends of the two small RNA strands determine which strand of the small RNA duplex is assembled into fly Ago2 [8], plant AGO1 [9] or mammalian Argonaute proteins [6,7].
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