Nevertheless, several studies including thousands of critically ill patients have seemingly disapproved the Starling principle [10 15], concluding that there were only marginal differences in the administered volume of crystalloid and colloid solutions.
First, there may be differences in the administered doses and dosing schemes.
Meta-regression showed that for most outcome measures, differences in the administered cell type did not explain variations in treatment effect.
We also utilized another statistical analysis to determine whether longitudinal changes in the regional wS2 curves were affected by differences in the administered radiotracer dose at baseline and follow-up time points.
The route of administration also changed significantly: after implementation, more patients received medication p.o. (comparable with the difference in the administered acetaminophen).
Patients without bone marrow involvement did not have any grade IV haematological toxicity (Table 5).There was no significant difference in the administered first I-MIBG dose between patients with and without haematological toxicity (P = 0.269).
We have noted a significant difference in the administered calories in the TPN group compared with the EN group on the first and third days of follow-up, as well as a larger energy intake administered the first day of nutrition in the group of patients who developed LD.
There were no significant differences in the proportion administered anti-MRSA drugs, carbapenem, tazobactam/piperacillin, or fourth-generation cephalosporins after day 2 in the propensity-matched groups undergoing mechanical ventilation.
7, 9 Analyses carried out within the Italian health care system 10, 11 have demonstrated that differences in the methods of administering the two drugs, (by infusion or orally), and their toxicity profiles affect patient quality of life.
Other explanations are differences in the specific vaccines administered or methods of administration, chance, or some other unmeasured factor.
