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The differences in significance of the odds ratios in two of the genomic features between the two methods are most likely caused by the differences of theoretical versus empirical confidence intervals (see Discussion, which highlights the value of the empirical method (circular permutations)).
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To evaluate the difference in significance of coefficients and variance explained from modeling temperature regimes near the ground versus at 2 m, we estimated and compared two simple GLMs based on observed maximum temperatures at 0.05 and 2 m above the ground surface.
However, the difference in significance of upregulation between the two genes might be due to their different constitutive expression.
Application of the pathology-based algorithm tended to shift estimates and 95% CIs farther from the null, although there was no appreciable difference in significance of estimates when the algorithm was not implemented (Additional file 1: Table S3).
Sex-and-age-stratified analysis revealed slight differences in significance and magnitude of associations across subgroups.
Possible differences in clinical significance of anti-RHA in different races should be clarified in future studies.
Gene function is another factor causing differences in biological significance of a PCC value.
We found differences in prognostic significance of TIL markers, depending on the separate areas.
Interestingly, we observed differences in prognostic significance of TAMs that was dependent on the tumour compartment.
This term is normalized in a sex-specific manner, perhaps reflecting sex-specific differences in the significance of neutrophil counts in CAD and MI [ 26].
Graphs identifying the overall differences in the significance of P-values (chromatin state changes) were generated by computing the -log10 value of the sum of the P-values.
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