It should also be noted that different fish species respond at different rates to stimulation (differences in responsiveness).
Poor correlation or differences in responsiveness of different instruments could be a potential threat to the validity of results.
Second, because a limited number of patients is enrolled in phase II protocols, dose selection for phase III studies based on differences in responsiveness to different drug doses in phase II trials may be suboptimal.
A difference in control and plasticity of synaptic inhibition might then be responsible for the differences in responsiveness to TUT and CON between repeaters and non-repeaters.
Individual differences in the relief response were also related to differences in responsiveness to the threat of pain, as measured by dread and pessimism scores.
Interestingly, looking at response to therapy across the different breast cancer subclasses [ 23, 25], some differences in responsiveness could be detected.
Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug.
Overall, our results indicate that the noncanonical nature of the cis-acting elements that enables p53 and ER cooperation at the FLT1 promoter provides higher potential for adaptive tuning of the transcriptional responses compared to highly responsive p53 target genes, such as p21, and may suggest differences in responsiveness to altered function p53 mutants [27].
Our data suggest that differences in responsiveness to rapamycin could be due to expression levels of the different FKBP proteins, specifically FKBP12 and FKBP51.
Since the publication of seminal work on gene-environment interactions (Caspi et al., 2002, 2003), gene-environment interaction has become quite common in investigations of individual differences in responsiveness to environmental factors.
Specifically, it was intended to test whether or not the three personality dimensions – harm avoidance (HA), reward dependence (RD) and novelty seeking (NS) – as suggested by Cloninger, can predict inter-personal differences in responsiveness to morphine after exposure to experimental cold pain.
