Specific chemokines and their receptors are expressed on different cell types, and therefore, relative differences in receptor distribution and affinity for specific chemokines may significantly influence which cells are ultimately attracted to and activated by the individual chemokine.
In addition, affinity measured by the different assays cannot be directly compared, as differences in receptor reserve and amplification must be taken into account.
To investigate the molecular determinants for the differences in receptor kinetics, affinity and antagonistic potency of clozapine we constructed different chimeric receptors between human and murine 5-HT3 receptor sequences.
Older women could legitimately receive different treatment to younger women owing to, for example, larger tumour size or differences in receptor status (COIN, 1999; SIGN, 2005).
These studies revealed differences in receptor kinetics depending on the type of dimers.
Female offspring displayed no differences in receptor binding in either region.
Investigations like this may prove to be useful to qualitatively predict differences in receptor residence times for structurally closely related ligands.
After classifying images of the receptor into groups with high similarity, we were able to see differences in receptor density consistent with the known variability in receptor glycosylation.
The differences in receptor distribution between humans and avian species are thought to determine the host restriction of influenza A viruses.
Additionally, the biochemical assay cannot measure heterogeneity in individual cells, in contrast the flow cytometric one enables the enumeration of the receptor on a per cell basis, allowing exact description of differences in receptor levels amongst intact cells.
Despite the promiscuous interactions recent data reveal differences in receptor recruitment, architectures of these assemblies and specific modulation by a multitude of extracellular as well as membrane-associated factors.
