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Conclusion: Integreation of age and gender differences in quantification of DaTscan is feasible and applicable in clinical routine.
A possible reason for the inconsistent findings could be related to the methodological differences between investigations including differences in quantification of disability (e.g., self-report versus clinically determined) and cognitive task utilized.
It is likely that the limited number of reports found in the literature is due to methodological differences in quantification of SH as well as a lack of standardized definitions for periventricular, deep white, and lacunar-like, cystic fluid-filled infarcts [ 2, 15, 69, 70].
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In practice, no significant difference in quantification of malignant lesions is found comparing CT-based attenuation correction with segmented AC (SAC) using transmission imaging [ 28] or between measured (MAC) and segmented (SAC) attenuation correction using transmission imaging [ 29].
It is also possible that some of the large observed differences in absolute quantification of many primary metabolites may be due to the smaller average cell size of the rhizome apical tip and elongation zone compared to the more mature tissues analyzed from the leaf, root and stem, which contain much larger vacuoles as well as fiber cells.
A brief discussion of the seeming discrepancy between the differences in quantification may help the reader.
To minimise systematic differences in quantification, three measures were taken.
This is possibly related to the difference between the studied populations or the difference in the quantification of detached glycans and glycopeptides.
While no significant difference in the quantification of synovial F4/80 staining was observed in synovial tissue for WT and IL-10KO mice, an increased localization of F4/80 staining was observed around sites of focal bone erosions in sections from AIA-challenged IL-10KO mice.
This is due to the difference in quantification methods, the absolute quantification of integrated HIV-1 DNA being corrected by using an integration standard as calibrator as previously described (Liszewski et al., 2009; De Spiegelaere et al., 2014).
Although no significant difference in the quantification of the pimonidazole staining was detectable, a qualitative trend of decreased staining density was observed in the long-term study (see Figure 5).
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