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The molecular BC subtypes have repeatedly been shown to display different CNAs [ 36, 49, 50], and, lately, also differences in fractions of LOH and CNN-AI [ 10].
The differences in fractions of steatosis were analyzed by McNemar's Test for paired categorical data.
The difference between cluster 1 samples and the remaining normal samples could be due to differences in fractions of the cell types present in the biopsies.
Finally, another reason we may not have found differences in fractions of antagonistic QTL between traits subject to abiotic and biotic selective pressures is that abiotic selection can also have discrete optima of high fitness in their adaptive landscapes; for example, selection has resulted in discrete strategies for adaptation to drought and freezing, such as avoidance or tolerance.
This bias may have prevented us from detecting differences in fractions of antagonistic QTL between abiotic and biotic traits independent of cross type, because, in previous work, interspecific crosses have lower fractions of antagonistic QTL than intraspecific crosses in wild populations [ 4].
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We detected no differences in fraction of antagonistic QTL across trait types.
This can be explained by a difference in fractions of immediate cases.
Thus while the difference in fractions of ancient genes is suggestive, we cannot currently conclude anything from this finding.
However, comparison between ATG and GTG triplets that function as start codons and those that are not translation start sites shows no significant difference in fractions of ATG/GTG triplets overlapping with extended RY patterns between the two groups (Supplementary Table S18).
The unstandardized regression coefficients (b) therefore show adjusted group mean differences scaled in fractions of a standard deviation (SD) for the dependent variables.
Interestingly, leptin KO AL mice showed no statistically significant difference in fraction of high activity relative to the leptin KO CR group (Fig. 4B).
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