Historically, however, Fluorescence Recovery After Photobleaching (FRAP), which requires confocal laser scanning microscopy, has been the most widely used assay to determine differences in diffusion rates of GFP-tagged bromodomains in the presence or absence of small-molecule inhibitors [ 9].
Furthermore, it is shown that for very fast reactions differences in diffusion coefficients of the intermediates influence the by-product formation.
Adapting voxel-based morphometry used in structural MRI [10], the voxel-based analysis of DTI serves as an exploratory analysis to make statistical inferences about differences in diffusion properties of brain tissues in an atlas coordinate system.
On the other hand, differences in diffusion anisotropy of the anterior corpus callosum fibres between FTD and Alzheimer's disease disappeared when analysed in terms of Dra.
Basically, the differences in inhibition of yeast strain obtained from essential oil (liquid phase, direct contact with the culture media) and the vapour can be attributed to the differences in diffusion coefficients of the antimicrobial compounds present in the eucalyptus oil when they have to diffuse in the agar compared to the diffusion in vapour phase [ 35].
By using the appropriate MR sequences that are sensitive for diffusion, these differences in diffusion rates (magnitude of diffusion) can be translated into image contrast (Fig. 1).
This allowed us to ensure that estimates of diffusivity and diffusion anisotropy across session were mapped to the same anatomical location for each subject, since slight differences in diffusion properties over the course of intervention can influence the region of interest that is identified by the tractography algorithm.
In fact, Pierpaoli et al. conclude that they were "unable to identify a single microstructural factor or a combination of them to account for the observed differences in diffusion anisotropy in all regions of white matter in the normal human brain" (p. 646).
Next we stratify PUNCH scores in our ASD sample and show how severity moderates findings of group differences in diffusion weighted brain imaging data; more severely affected subgroups of ASD show expanded differences compared to age and gender matched healthy controls.
It was found that pressure gradients are induced within the porous solids by differences in diffusion rates, adsorptivities and adsorption rates of the counter-diffusing gases.
