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To handle this aspect of reporting for such a wide range of interventions, we classified interventions according to their degree of cost effectiveness (not cost effective, cost effective, or very cost effective) in order to ascertain order of magnitude differences in cost effectiveness.
For all results we find that the 95% confidence intervals are much smaller than the reported differences in cost effectiveness ratios for different strategies.
MANOVA could not detect any differences in cost effectiveness for the four levels of PTAMs (p = 0.636; Fig. 1 ).
Firstly, results were placed on a logarithmic scale in order to ascertain order of magnitude differences in cost effectiveness (for example, $Int10 100 v $Int100 1000 per DALY averted).
Differences in cost effectiveness of ACEI versus ARB could not be solidly established because of differences in model design, time horizon and country setting among all included studies and lack of head-to-head comparisons in economic evaluations.
To handle this aspect of reporting for such a wide range of interventions, we first placed intervention results on a logarithmic scale, with a view to ascertaining order of magnitude differences in cost effectiveness (such as $Int10 100 versus $Int100 1000 per DALY averted).
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This paper investigates the difference in cost effectiveness resulting from models based on visual acuity and contrast sensitivity using the example of bevacizumab (Avastin) for neovascular AMD.
In summary, the observed sub cohort difference in cost effectiveness can be explained as an epi-phenomenon of a preoperative gradient in algo-functional status among the respective cohorts.
Hence, the difference in cost effectiveness is driven by the difference in acquisition costs of the study drugs and the difference in their effectiveness, i.e. the difference in the probabilities to move between disease states and the differences in exacerbation risks.
The differences between drugs in dosing and administration, however, may lead to differences in cost-effectiveness.
The true value of a cost-effectiveness study occurs when differences in cost-effectiveness cannot be explained by costs alone.
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