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The total number of polymorphic sites (length of the concatenate) observed among isolates was 270 with 591 different differences in base composition.
While the method is not expected to precisely quantify the amount of base flow in a stream, the BFI has been found to be a reasonable indicator of differences in base flow among different streams (Wahl and Wahl 1995).
Although this method will be biased if base composition differs between groups, the slight differences in base composition between species (%A/T = 75.6% in C. elegans and 75.1% in C. briggsae) and the even smaller difference between strains of C. briggsae (<0.1%) mean that the test is essentially unbiased as applied to our data.
Animal mitochondrial DNA has two strands of different mutation pressure which leads to differences in base frequencies between the two strands, usually with H strand being GT-rich and L strand being CA-rich [1].
We have shown above that our composition profiles are caused by CpG islands, so we can expect to see differences in base composition between genes with different expression patterns.
Although deposited under similar conditions of high-frequency sea-level fluctuations, these two types of platforms exhibit different internal facies architecture and distribution of heterogeneities, because of differences in base level.
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Despite differences in base-line characteristics and patient management, 30-day mortality was not significantly different: 6.8% in the United States vs 7.2% elsewhere (P =.09).
In our study we did not find differences in base-line parameters between Sfrp1 −/− or Frzb −/− mice and littermates, including pulmonary function tests and μCT imaging.
In fact, there were some small but significant differences in base-line characteristics between participants of the intervention and concurrent comparison groups.
P-values for differences in base-line characteristics were derived from multivariable logistic regression analyses with a covariate pool consisting of the individual base-line items.
Multivariate modelling was not used since the study was a randomized trial and there were no differences in base-line confounding factors between the groups.
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