Although reproducible and statistically significant, suppressive effects of IGF-1Ea appeared reduced in these mice, potentially due to differences in genetic background that demanded the use of different CHS induction doses in order to yield comparable ear swelling responses (supplementary material Fig. S2).
To account for differences in genetic background that could alter signal intensities for individual assays, genotype calling was performed separately for each mapping population, along with the respective parental genotypes.
The results of this study show few differences in background factors that would indicate a difference in fertility based on sexual orientation.
Either there are differences in strain background that account for a disparity in growth data between different studies, or Cdkn1c mutant mice experience a loss of growth potential late in development.
Finally, differences in the association of the other MMPs and TIMPs with gastric cancer survival between our study and other reports, as mentioned above, might be related to differences in genetic background, that is, Caucasian vs Asian, which is currently under study.
This discrepancy might be related to differences in the genetic background that apparently causes a more severe phenotype in C57Bl/6 as illustrated by the strongly reduced mendelian ratio (data not shown) (Tominaga et al, 2008), in comparison with our results obtained from a mixed genetic background.
Joint analyses of the 5- or 8-month-old fishes, respectively, provided no significant or suggestive QTL, probably due to differences in strain genetic background that influences the degree of QTL expression as reported by Wringe et al. [ 43] or the existence of another uncontrolled factor in each family.
It is conceivable that differences in background risk factor profiles (menopausal status, reproductive factors, obesity, or dietary intake) contribute to these variations.
8) The KO mice need to be backcrossed into the background strain for multiple generations in order to be certain that differences in background aren't responsible for the effects attributed to P-2.
Selectivity and survival bias were concerns in this analysis; we attempted to account for these by adjusting for differences in background characteristics and by excluding deaths that occurred up to the day of visit.
