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Owing to differences between the screening programmes and study designs, further comparison between both studies is limited.
These results demonstrate that the intrinsic differences between the screening approaches influence how much they can complement each other.
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There were minor differences between the screened and non-screened regions in pre-screening incidence (Table 1 and 3).
Differences between the study population and the West of Scotland will therefore reflect differences between the screened and non-screened women.
For instance, SMA was modified to deal with unbalanced experimental designs, as well as differences between the screens, resulting in potentially highly rectangular, asymmetric matrices W [58], such as those provided with the SGA and GIM datasets.
In all, however, the differences between the screens are not unusual.
Data needed for a proper understanding of differences between the SCREEN project and the national screening programme are lacking.
The other five trials were rejected on the grounds of perceived differences between the screened and unscreened groups at baseline.
In the present study, we have noted differences between the screened group and the unscreened controls regarding treatment (Table 3), which are possibly explained by our screening intervention.
A major strength of these data is the high screening rate (70% of all women were screened), reducing the potential for differences between the screened and target population.
The clinical pathological factors for the two cohorts are shown in Tab. 2. There were significant differences between the screen-detected and non-screen-detected cancers with respect to clinical/pathological prognostic factors (all P < 0.0001).
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