Previous studies have identified distinct differences between the regulation of HKI and HKII [7], [8].
These interactions may explain reported differences between the regulation of PKG and PKA, such as the reversed order of the high and low affinity CNBDs and differences in cyclic nucleotide induced conformational changes, as revealed by small angle X-ray scattering [5], [31].
Differences between the regulation of clock genes in humans versus rodents have been observed.
The analysis exploits the subtle differences between the regulation of cell proliferation and nuclear size across 93 mutations.
It is interesting to note that yeast PDI is predominantly oxidised in vivo (Xiao et al, 2004), suggesting clear differences between the regulation of Ero1p and Ero1α in terms of their ability to be activated and to oxidise PDI.
Because there are evident differences between the regulation of mouse and human pluripotent ESCs (Hackett and Surani, 2014; Nichols and Smith, 2009) and during their early postimplantation development (de Fellici, 2013; De Miguel et al., 2010; Irie et al., 2014), this might affect the mechanism and the role of the key regulators of hPGCLC specification (Imamura et al., 2014; Pera, 2013).
There is thus a fundamental difference between the regulation of gene expression in germ cells and soma, as perhaps there should be given the germline's connectivity of generations that span millennia, versus the soma's single generation relevance.
As previous studies reporting a direct interaction of CED-9 and CED-4 at mitochondria were performed in embryos, we reasoned that our results could be explained by the existence of a fundamental difference between the regulation of developmental apoptosis and germ cell apoptosis.
Yet, this assumption leaves out the case of dual EPL regimes which have been prevalent in several southern European countries, where there are substantial differences between the dismissal regulations pertaining to workers under permanent (open-ended) and temporary (fixed-term) contracts.
For dose response curves, repeated measures MANOVA was used to assess statin-induced differences between the up-regulation of the HMGCR13 and 13 transcripts.
