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One major difference between our study and the studies of others was that we did not find any differences between the late onset preeclampsia and the two control groups at any of the measured time points.
Notably, promyogenic transcription factors were strongly modified with H3K27me3 but showed no differences between the late gestation foetus and lamb, likely reflecting their lack of involvement in the myofibre fusion process occurring in this transition.
There were statistically significant differences between the late H/M ratios at 1, 2 and 3 h p.i. compared with the late H/M ratio at 4 h p.i.
However, none of the mean differences between the late H/M ratios at 1, 2 and 3 h p.i. exceeded the predefined clinically relevant 0.10 difference with the late H/M ratio at 4 h p.i. (Fig. 1a).
An example of a patient with only small differences between the late H/M ratios at 1, 2 and 3 h p.i. compared with the late H/M ratio at 4 h p.i. is depicted in Fig. 2.
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There was no difference between the late and early TPN cohort in the need of mechanical ventilation in the first 72 hours (61/70 (87%) vs 54/73 (75%); NS), total duration of mechanical ventilation (median days [IQR]: 10 (3–19) vs 11 (3.5–17.5); NS), and surfactant treatment (48/70 (70%) vs 48/73 (66%); NS).
There was no difference between the late and early regression in 5-year local control rate (82%% vs. 77 %), regional and distant metastasis-free rate (69%% vs. 72%%) and overall survival (75%% vs. 79%%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com