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Explanations for this include differences between the investigators' assessment according to RECIST 1.0 or 1.1 (depending on the studies) and our reassessment according to RECIST 1.1, and withdrawal from study because of clinical progression.
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A few differences existed between the investigators about articles extracted but all disagreements were resolved through discussion and consensus.
There were no significant differences between the 5 ICU investigators and the 2 neuropsychological experts (kappa coefficients ranging from 0.82 ± 0.1 to 0.88 ± 0.2).
A repeat cell count was performed by the neuro-pathologist on samples in which there was greater than a 3% difference between the two investigators.
There were only minor differences between the symptom ratings by the investigators and by the patients (Fig. 3).
Although the investigators detected differences between the groups, all three groups reported significant decreases in their drinking over the course of the study, indicating reactivity to the EMA procedure itself and suggesting the presence of a "floor effect".
Differences between investigators were settled by consensus of all investigators as to whether the pre-specified inclusion and exclusion criteria were met.
Interestingly the investigators report substantial differences between the three countries with respect to more specific characteristics and consequences of climate change, such as the main consequences of climate change.
These investigators reported differences between the spatial EEG patterns of the two agents.
The investigators found distinct metabolic differences between the tumor and the adjacent normal brain.
In the event of differences between investigators, a final disposition was reached by consensus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com