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Comparative genomic hybridization (CGH) is a powerful technique to determine the differences between the genomes of different cell types or organisms.
This was an expected magnitude, similar to a previous study that also mapped a diploid strain to S288c [ 37], and it reflected the marked differences between the genomes of different strains in general, and between the genomes of laboratory and industrial strains in particular [ 38, 39].
Furthermore, we aligned the obtained sequence read to the complete genome of another E. coli strain, W3110 [6], to detect sequence differences between the genomes of two different E. coli strains.
Despite some clear differences between the genomes of archaea and eukaryotes for example, genomic DNA is typically circular in archaea and linear in eukaryotes they found that the genome of Hfx.
Comparative genomics indicated that the most striking differences between the genomes of IA3902 and NCTC11168 were located within the loci encoding genes involved in biosynthesis and post-translational modification of capsule and flagellin (O-linked glycosylation).
The differences between the genomes of these serovars suggest they have been exposed to different stresses including, phage, transposons and prolonged externalisation.
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One major difference between the genomes of prokaryotes and eukaryotes is that most eukaryotes contain repetitive DNA, with the repeats either clustered or spread out between the unique genes.
Yet, there is very little difference between the genomes of carrier and invasive strains [18].
The most prominent difference between the genomes of CS-505 and D9 is the overwhelming number of repeated insertion elements or transposon-derived sequences in the CS-505 genome, which accounts for a considerable part of the genome size difference (nearly 0.6 Mb or 20% of the D9 genome) between the two strains (Table 1).
The most dramatic difference between the genomes of R. peacockii and R. rickettsii is the presence of the ISRpe1 transposon and the effects multiple transposon copies have had as a point of homology for recombination, resulting in numerous deletions and genome shuffling (this manuscript).
One significant difference between the genomes of C. elegans and Saccharomyces cerevisiae that presents a particular challenge to a biologist studying gene function is the expansion of shared gene families and the derivation of whole new gene families as one moves from a single-cell organism to the complexity of a multicellular organism.
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