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Setting the vaccination studies aside, there are differences between the conclusions drawn from the studies looking at natural immunity and those obtained in this study.
The differences between the conclusions may have been due to collecting similar data, analyzing it slightly differently and subsequently finding a different conclusion.
We are reassured that no major differences between the conclusions would be drawn using complete cases compared to those where data was missing and imputed.
However, we have considered this issue by using multiple imputation and were reassured when we found no essential differences between the conclusions that would be drawn using complete cases compared to those where missing data have been imputed.
Differences in the temperature-mortality parameterization probably explain many of the differences between the conclusions of recent studies on the effects of heat waves [ 6, 8, 9, 11- 19, 19, 21] In our example we found that a simple model for the temperature-mortality association was better than a complex model.
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In summary, the difference between the conclusions made by Yahara and us does not result from model differences (see Additional file 1, Table S1), but rather from the fact that Yahara et al. did not explore the parameter space exhaustively.
In light of these differences between reviews, the conclusions below about specific components should be regarded as tentative.
Differences in intrinsic EGFR tumoral expression may modulate the final impact of the dual EGFR targeting and explain the differences between the present conclusions and those reported by the two other groups (Huang et al, 2004; Matar et al, 2004).
The difference between these conclusions and those of Goldman and Welch may rest upon the differently phrased survey questions on which they base their conclusions.
However, the heterogeneity of TNBC, follow-up time, case number and other limitations may also explain the differences between our conclusions and those of previous studies.
If we don't take the differences between the studies into account, the conclusions of our meta-analysis may be misleading.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com