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Their factor analysis of key components, followed by a variance analysis comparing the effects of the four types of treatment, showed statistically significant differences between combined and other treatments and the former led to greater short- and long-term benefits.
These inverse findings of PSF and TOF may explain why no correlation was observed for differences between combined PSF + TOF and 3D-OSEM (non-PSF, non-TOF) and the TBR.
Q-statistics and p-values were also computed to assess differences between combined effect sizes for specific subsets of study effect sizes grouped by moderators.
Although diazepam has been demonstrated not only superior to pill-placebo but also equally effective compared with alprazolam [ 56, 58], this issue could have diminished efficacy of diazepam and have diluted differences between combined therapy and psychotherapy alone.
Overall, there were no differences between combined LY2605541 and GL with regard to incidence of total hypoglycemia (54.4 vs. 63.4%, P = 0.162) and nocturnal hypoglycemia (25.6 vs. 34.4%, P = 0.127).
Based on end point 8-point SMBG profiles, there were no differences between combined LY2605541 and GL daily mean BG (SMBG) (Table 2) or most categorical SMBG time points at end point, although, a significantly greater reduction from baseline in daily mean BG was observed with combined LY2605541 versus GL (P = 0.017).
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There are several differences between combining and merging knowledge bases.
Analysis of the primary endpoint (ie, ACR20 response at week 14) demonstrated a significant difference between combined Groups 2 and 3 (73.4%, 127/173) and Group 1 (27.3%, 24/88) (p<0.0001; table 2).
An interesting note is that there is a notable difference between combining logics from the syntactical and from the semantical perspective.
The present study was not powered to detect differences between different combined doses of tiotropium + olodaterol, but it was sufficient to identify dose ordering for FEV1 responses for the dose combinations.
Compared to physical exercise, combined intervention produced greater effects on overall effect size (0.22, p < 0.01), while no significant difference was found between combined intervention and cognitive intervention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com