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Variability of allele frequencies in controls between the Oxford cohort and the two cohorts from the European mainland might be explained by population differences as a consequence of a heterogenic ethnical history.
Given the heterogeneous nature of MS we questioned whether the observed poor yield of response genes upon IFNß treatment of the whole MS cohort could be a reflection of averaging out differences as a consequence of variation in pharmacological responsiveness between the patients.
Smaller between-person differences, as a consequence of stricter inclusion criteria, may have a substantial (negative) impact on correlation coefficients.
ESC lines are known to display differences, as a consequence of culture conditions, in genetic and epigenetic stability and genetic variation.
Thus, the day 7 concentration of lumefantrine may not always correlate fully with cure rate, and variation might be due to ethnicity and/or regional differences as a consequence of lower background immunity and/or reduced susceptibility (13).
In leaves of wt plants, ACC concentration increased by 90% as a result of inoculation with Bacillus megaterium, while in leaves of mutant plants there were no significant differences as a consequence of inoculation.
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He interpreted this difference as a consequence of the warmer room conditions and tested this new hypothesis.
Both male and female Cgl mice exhibited massive accumulation of plasma cystathionine compared to WT controls but showed no significant difference as a consequence of sex (P=0.1581).
Morasso and Schieppati [ 5] showed the acceleration of the CM correlates highly with the CM-CP difference, as a consequence of physical laws.
Again, we interpret this difference as a consequence of the negative selection that acts against mono-SSRs longer than 6 units in the coding sequences.
In addition differential expression patterns indicate that the genes might be involved in the mechanism(s) resulting in phenotypic differences, either as a consequence of a polymorphism in an upstream gene or in the gene itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com