Because the magnitude of detection threshold may be larger than 3.0 in the lapse times earlier than about 0.1 day, the difference of p value obtained at different time periods could be biased to some extent.
The difference of P values with less than 0.05 was considered significant in all experiments and is indicated by symbols and the difference of P values with less than 0.01 was considered extremely significant.
In the dip test for these two situations, we found significant difference of p values between these two groups.
A subtle difference is seen when the proximal phosphosites were separated from the rest of the S/T phosphosites (a significant difference of p-value 4.07e-21, Figure 6B).
The null hypothesis is that the median difference of the P-values in the Mann–Whitney test for each SNP is zero.
For mouse, the mean of the differences of the p-values is −0.1938 between STRING and iRefIndex, and based on a one-sided paired t-test this difference is significantly smaller than 0 with p-value = 0.002.
For human, the mean of the differences of the p-values is -0.05209, which is not significantly smaller than 0 (one-side paired t-test, p-value = 0.187).
Thirteen of the 24 analyzed graphic criteria displayed differences of the p-values ≤ 0.001.
We rejected null hypotheses of no difference if p-values were less than 0.05.
