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In any case, investigators should take stock in the fact that deltas of 10% or greater are rarely found, and attention needs to be refocused on what is the minimal clinically important difference in trials of therapies to reduce mortality in critical illness [ 9, 31].
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This improvement was greater than the 100 140 ml outcome recently suggested to be of a minimal important difference in clinical trials of COPD.
However, a statistically significant and clinically meaningful (>1 day) difference in weaning duration was found in trials of mixed and medical ICU populations and SmartCare/PS™.
Even with the effect of same-trial facilitation nulled, the upper graph of Figure 4A shows a difference in trial-over-trial depression of about 5 spikes/s between '1-1' pairs (green trace) and '0-0' pairs (blue trace).
Another major difference in trial design is the use of open- or double-blinded methodology.
The difference in end-of-trial basal insulin doses between IDeg(A) and IGlar reflected the fact that a higher basal insulin dose was used in the IDeg(A) group already at study entry.
We found no significant difference in terms of trials' characteristics between trials that were sponsored by pharmaceutical industry or not (data not shown).
One of the major differences in trial design was the number of treatment cycles administered.
The scientific implications of participant recruitment from these diverse geographic regions and of the differences in trial characteristics in different regions warrant further exploration.
Differences in trial initiation speed, proportions of trials completed would be sufficient I think.
3 Since then, follow-up studies have shown conflicting results, 4– 6 due to differences in trial design and lack of pharmacokinetic measurements.
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