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In addition to a higher innovation fraction for the social science paradigms, there is also a marked difference in the turnover in keywords.
Lastly, we observed little difference in the turnover between nearly all modified forms of the H3.1, H3.2 and H3.3 variants, with the notable exception that H3.2K36me2 has a faster turnover than this mark on the other H3 variants.
It is worth noting that replacing thiosulfate with p-Tol-SO2S– appears to eliminate the difference in the turnover rate of the human and yeast enzymes that is observed with the less reactive donor (see Table 2).
These results are consistent with a previous deuterated glucose labeling study, which reported no significant age-related difference in the turnover of total B cells (Macallan et al., 2005), and we extend these insights by showing that also within the different B-cell subsets as well as for γδ T cells, turnover rates do not change during healthy aging.
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Isotopic variations of a few permil among organs may be explained by the differences in the turnover rates of proteins.
A treatment with cordycepin, which inhibits transcription of mitochondrial DNA [18], does not reveal any temperature-specific differences in the turnover rates for the polyadenylated transcripts of the model transcript.
The model can be used to statistically test for relative differences in the turnover rate and equilibrium density of TFBSs as well as gain insights into the actual rate of binding site turnover.
We also found that the expression level of the CI-MPR, SorLA, and Sortilin are unaltered in brain tissue of Gga2 −/− mice, excluding major differences in the turnover of these receptors in the absence of GGA2.
In order to study the observed differences in the turnover of H2A.Zac and H3K9ac in more detail and to elucidate the influence of HBV-suppressive interventions, we went on to analyze histone PTM patterns by chromatin immunoprecipitation (ChIP) and qPCR.
Both MDA-MB-468 and BT-20 display a less dramatic decrease of MUC1 extracellular domain compared to MUC1-CT; this likely represents protein synthesized prior to transfection, and may reflect differences in the turnover rates of the two subunits.
This difference between the expression of the native protein and the transgenic protein has been observed before (Lee et al., 2001), is also seen in mice in which the EGFP coding sequence replaces the neurogenin-3 coding sequence directly in the Neurog3 locus (Neurog3 EGFP/+ mice; supplementary material Fig. S1G L), and most probably reflects differences in the turnover of the two proteins.
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