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There was no difference in the TRAIL mRNA gene expression ratio between MS patients and controls.
Statistically significant differences in secondary endpoints were similarly modest, and there was no difference in the Trail Making Test Part B. Of note, the only hard clinical endpoint in any of the three trials – days alive and out of the hospital at 60 days, was not different between the two groups.
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Differences in the Trail Making Test Part B were, again, nonsignificant between the two groups.
Despite the clear advantages of in vivo systems to address our question, they could not be used due to the significant differences in the TRAIL receptor family as well as the regulation of TRAIL sensitivity between human and rodent cells.
There were significant overall group differences in the Trail Making Test B, the WMS-R Visual Reproduction test, the WAIS Digit Symbol test, and the composite z score (p's ≤ 0.040; Table 3).
The serum TRAIL level was lower in MS patients compared to controls but no difference was seen in the TRAIL mRNA gene expression ratio.
No significant difference in the response to TRAIL and/or bortezomib was observed between Bid knockdown and control cells, indicating that bortezomib-induced sensitisation to TRAIL occurs independently of Bid.
However, our study did not find any significant difference in the TIL apoptosis rate between focal TRAIL-positive and TRAIL-negative OSCC.
For a time, that was the difference in the game as the Lakers trailed by 19 points late in the second quarter.
Although there was no significant difference in response to TRAIL stimulation, the mesenchymal cells demonstrate resistance to TGFβ-induced apoptosis, a characteristic of TISCs [ 40].
However, it was not known whether there was a difference in TRAIL sensitivity between adenoma and carcinoma cells and whether TRAIL receptor expression on the cell surface, rather than intracellular receptor pools, would correlate with sensitivity to TRAIL-induced apoptosis.
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