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Previous studies have found little difference in the mutation rates or mutational spectra of mutL and mutS mutant strains (Schaaper and Dunn 1987).
The total number of mutations per strain ranged from 23 to 240; however, there was no significant difference in the mutation load arising from different 4-NQO doses and kill percentages.
No difference in the mutation frequency was observed between the Greek and Romanian population.
Additionally, there was no statistically significant difference in the mutation frequency between the two populations.
However, there is not a sharp difference in the mutation distribution plots for the overlapping and non-overlapping data sets.
There was no significant difference in the mutation loads observed at the three sites (Friedman test P = 0.36).
Similar(36)
The most obvious difference in the mutations borne by these elements is that in the internal deletion mutant both ORF1 and ORF2 are likely inactivated, whereas only ORF2 is inactivated in the other two.
The different parts of the genome have differences in the mutation rate and the accepted selection pressure.
Differences in the mutation rate in different parts of the genome would contribute to this rate variation, as would differences in the number of sites under nonthermodynamic constraints such as the requirements of functionality (Zuckerkandl 1976).
In MMR-deficient cells, significant differences in the mutation rate were observed among these DNA sequences reflecting the different rate of replication errors.
Furthermore, there were differences in the mutation rate among autosomes.
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